Bioactive peptides derived from food proteins preventing lifestyle‐related diseases

作者：Masaaki Yoshikawa, Hiroyuki Fujita, Nobuyuki Matoba, Yasuyuki Takenaka, Taichi Yamamoto, Rena Yamauchi, Hirotaka Tsuruki, Kyoya Takahata · 发表于：BioFactors · 年份：2000 · DOI：10.1002/biof.5520120122 · 被引用次数：248 · 研究领域：Protein Hydrolysis and Bioactive Peptides、Biochemical effects in animals、Muscle metabolism and nutrition

Many kinds of bioactive peptides which might prevent lifestyle-related diseases are released from food proteins after enzymatic digestion. Inhibitory peptides for angiotensin I-converting enzyme (ACE) having anti-hypertensive effect have been isolated from enzymatic digests of various food proteins. LKPNM, which was isolated from the thermolysin digest of dried bonito was activated 8-fold by ACE itself and showed a prolonged effect after oral administration. Two vasorelaxing peptides, ovokinin and ovokinin(2-7), showing antihypertensive effect after oral administration were obtained from ovalbumin digests. We found that low molecular weight peptides derived from food proteins lowered serum cholesterol without increasing excretion of cholesterol and bile acids. An immunostimulating peptide isolated from an enzymatic digest of soybean protein prevented alopecia induced by cancer chemotherapy.