Steroid receptor heterodimerization demonstrated in vitro and in vivo.

作者：W Liu, Jian Wang, N K Sauter, David Pearce · 发表于：Proceedings of the National Academy of Sciences · 年份：1995 · DOI：10.1073/pnas.92.26.12480 · 被引用次数：252 · 研究领域：Estrogen and related hormone effects、Hormonal Regulation and Hypertension、Nuclear Receptors and Signaling

The mineralocorticoid and glucocorticoid receptors (MR and GR, respectively) are members of the intracellular receptor superfamily that bind as homodimers to the same hormone response elements (HREs). Physiological evidence suggests that MR and GR interact with each other in cells that express both receptors, implying that they might directly interact in the regulation of transcription initiation. Indeed, we have found that coexpressed MR and GR interact functionally at the transcriptional level and furthermore that they interact physically through heterodimer formation at a shared HRE in vitro and in vivo. We suggest from these findings that heterodimerization may play an important role in steroid receptor transcriptional regulation.