Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis

作者：Erika C. Claud, W. Allan Walker · 发表于：The FASEB Journal · 年份：2001 · DOI：10.1096/fj.00-0833hyp · 被引用次数：414 · 研究领域：Infant Nutrition and Health、Neonatal Respiratory Health Research、Child Nutrition and Water Access

ABSTRACT Neonatal necrotizing enterocolitis (NEC) is a major cause of morbidity in preterm infants. We hypothesize that the intestinal injury in this disease is a consequence of synergy among three of the major risk factors for NEC: prematurity, enteral feeding, and bacterial colonization. Together these factors result in an exaggerated inflammatory response, leading to ischemic bowel necrosis. Human milk may decrease the incidence of NEC by decreasing pathogenic bacterial colonization, promoting growth of nonpathogenic flora, promoting maturation of the intestinal barrier, and ameliorating the proinflammatory response.— Claud, E. C., Walker, W. A. Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis. The FASEB J. 15, 1398–1403 (2001)