The role of bacterial biofilm in persistent infections and control strategies

作者：Li Chen, Yu‐Mei Wen · 发表于：International Journal of Oral Science · 年份：2011 · DOI：10.4248/ijos11022 · 被引用次数：282 · 研究领域：Bacterial biofilms and quorum sensing、Biochemical and Structural Characterization、Oral microbiology and periodontitis research

Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In hosts, biofilm formation may trigger drug resistance and inflammation, resulting in persistent infections. The clinical aspects of biofilm formation and leading strategies for biofilm inhibitors will be discussed in this mini-review.