3D Bioprinting of Vascularized, Heterogeneous Cell‐Laden Tissue Constructs

作者：David B. Kolesky, Ryan L. Truby, A. Sydney Gladman, Travis A. Busbee, Kimberly A. Homan, Jennifer A. Lewis · 发表于：Advanced Materials · 年份：2014 · DOI：10.1002/adma.201305506 · 被引用次数：2097 · 研究领域：3D Printing in Biomedical Research、Innovative Microfluidic and Catalytic Techniques Innovation、Pluripotent Stem Cells Research

A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co-printing multiple materials, known as bioinks, in three dimensions. These 3D micro-engineered environments open new -avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.