Regulation of Extravascular Coagulation by Microvascular Permeability

作者：Harold F. Dvorak, Donald R. Senger, Ann M. Dvořàk, V S Harvey, J McDonagh · 发表于：Science · 年份：1985 · DOI：10.1126/science.3975602 · 被引用次数：249 · 研究领域：Angiogenesis and VEGF in Cancer、Blood Coagulation and Thrombosis Mechanisms、Coagulation, Bradykinin, Polyphosphates, and Angioedema

Extravascular coagulation is a prominent feature of such important pathological processes as cellular immunity and neoplasia and has been thought to result from procoagulants associated with the inflammatory or tumor cells peculiar to these entities. It was found that increased microvascular permeability alone is sufficient to induce equivalent extravascular coagulation in several normal tissues. The results indicate that saturating levels of procoagulant are present even in normal tissues and that microvascular permeability is a rate-limiting step in extravascular coagulation.