Serum and Urine Markers of Bone Metabolism During the Year After Hip Fracture

作者：Janet Yu-Yahiro, Roger H. Michael, Norman H. Dubin, Kathleen M. Fox, Myron Sachs, William Hawkes, J. Richard Hebel, Sheryl Zimmerman, Jay R. Shapiro, Jay Magaziner · 发表于：Journal of the American Geriatrics Society · 年份：2001 · DOI：10.1046/j.1532-5415.2001.49177.x · 被引用次数：69 · 研究领域：Hip and Femur Fractures、Bone health and osteoporosis research、Bone and Joint Diseases

OBJECTIVE: As part of a larger study to describe indices of recovery during the year after hip fracture, the current prospective study investigated longitudinal changes in serum and urine markers of bone metabolism for the year after hip fracture and related them to bone mineral density (BMD). DESIGN: A representative subset of participants provided serum and urine samples and had bone density measured at 3, 10, 60, 180, and 365 days postfracture. SETTING: Two Baltimore hospitals. PARTICIPANTS: The subjects were 205 community-dwelling, white women age 65 and older with fresh proximal femur fractures. MEASUREMENTS: Samples were assayed for specific bone-related proteins and bone turnover markers, including serum osteocalcin (OC), procollagen type 1 carboxy-terminal extension peptide (PICP), bone-specific alkaline phosphatase (BAP), and urinary deoxypyridinoline (DPD) cross-links. Selected hormonal regulators of bone metabolism, including parathyroid hormone (PTH), calcitonin (CT), 1,25-dihydroxy vitamin D(3) (1,25 (OH)(2)D), and estrone (E(1)) were measured from serum samples. Repeated measures analyses were used to evaluate postfracture changes in each of the markers. RESULTS: BAP, OC, and PICP were most active during the early postfracture period (3-60 days). BAP and OC remained elevated at 365 days compared with 3 days. DPD rose 48% from 3 days to 60 days, but this difference was not statistically significant. PTH and 1,25 (OH)(2)D increased steadily and significantly from ...