Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice

作者：Laurence Struillou, Yves Cohen, Nacer Lounis, Guylène Bertrand, Jacques H.E. Grosset, J. L. Vildé, J J Pocidalo, Ch. Perronne · 发表于：Antimicrobial Agents and Chemotherapy · 年份：1995 · DOI：10.1128/aac.39.4.878 · 被引用次数：13 · 研究领域：Mycobacterium research and diagnosis、Antibiotic Resistance in Bacteria、Bacteriophages and microbial interactions

The activity of roxithromycin against three clinical isolates of Mycobacterium avium was compared with that of clarithromycin both in a model of infection of human monocyte-derived macrophages and in a model of established infection of C57BL/6 mice. In the cell culture model, roxithromycin and clarithromycin were bactericidal for strains MO-1 and N-92159 and bacteriostatic for strain N-93043. For the three strains, the differences between the intracellular activities of roxithromycin and clarithromycin were not singificant after 7 days of treatment. Mice were infected with the MO-1 strain. Drugs were given by gavage at a dosage of 200 mg/kg of body weight 6 days per week for 16 weeks starting 5 weeks after infection. At the end of treatment, clarithromycin was more effective than roxithromycin in lungs; roxithromycin was as effective as clarithromycin in spleens. Thus, the activity of roxithromycin was comparable to that of clarithromycin both in vitro and in vivo.