Morphogens, Compartments, and Pattern: Lessons from Drosophila?

作者：Peter Anthony Lawrence, Gary Struhl · 发表于：Cell · 年份：1996 · DOI：10.1016/s0092-8674(00)81297-0 · 被引用次数：566 · 研究领域：Developmental Biology and Gene Regulation、Hippo pathway signaling and YAP/TAZ、Wnt/β-catenin signaling in development and cancer

Over the last 20 years, the essential mechanisms of development have become clearer, mainly because modern molecular genetics has transformed traditional embryology. The longest dispute in embryology has been resolved: we now know that the adult is not preformed in the fertilized egg and that animals arise by step-by-step elaboration from simple beginnings, that is, by epigenesis. Much of this knowledge has come from ingenious experiments on invertebrates such as Drosophila and the nematode, Caenorhabditis elegans. Nevertheless, because so much of the genetic machinery is shared, many of the principles uncovered may apply, with variations, to all multicellular animals.