Claudins and the Modulation of Tight Junction Permeability

作者：Dorothee Günzel, Alan S.L. Yu · 发表于：Physiological Reviews · 年份：2013 · DOI：10.1152/physrev.00019.2012 · 被引用次数：1490 · 研究领域：Barrier Structure and Function Studies、Connexins and lens biology、Cancer-related molecular mechanisms research

Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes our current knowledge of this large protein family and discusses recent advances in our understanding of their structure and physiological functions.