A G Protein-Coupled Receptor Is a Plasma Membrane Receptor for the Plant Hormone Abscisic Acid

作者：Xigang Liu, Yanling Yue, Bin Li, Yanli Nie, Wei Li, Weihua Wu, Ligeng Ma · 发表于：Science · 年份：2007 · DOI：10.1126/science.1135882 · 被引用次数：380 · 研究领域：Plant Molecular Biology Research、Plant Stress Responses and Tolerance、Plant Reproductive Biology

The plant hormone abscisic acid (ABA) regulates many physiological and developmental processes in plants. The mechanism of ABA perception at the cell surface is not understood. Here, we report that a G protein-coupled receptor genetically and physically interacts with the G protein alpha subunit GPA1 to mediate all known ABA responses in Arabidopsis. Overexpressing this receptor results in an ABA-hypersensitive phenotype. This receptor binds ABA with high affinity at physiological concentration with expected kinetics and stereospecificity. The binding of ABA to the receptor leads to the dissociation of the receptor-GPA1 complex in yeast. Our results demonstrate that this G protein-coupled receptor is a plasma membrane ABA receptor.