DIURNAL VARIATIONS OF RENAL FUNCTION IN MAN

作者：Jonas H. Sirota, David S. Baldwin, Herman Villarreal · 发表于：Journal of Clinical Investigation · 年份：1950 · DOI：10.1172/jci102245 · 被引用次数：178 · 研究领域：Climate Change and Health Impacts、Thermoregulation and physiological responses、Circadian rhythm and melatonin

A diurnal rhythm in water and electrolyte excretion in man has been described by several investigators.Kleitman (1) reported decreased urine flow and chloride excretion during sleep as compared to "waking" hours, and suggested decreased blood pressure during sleep as the cause.Simpson (2, 3) confirmed these observations in young healthy adults who ingested the same amount of water at hourly intervals throughout 24 hours and suggested the acidosis of sleep, with the resultant intracellular shift of chloride and water, as a possible mechanism for the positive balance of these substances during sleep.Man- chester (4) studied the 24 hour variations of wa- ter and mineral balance in two epileptic children on graded activity.He found that the maximum excretion of water, sodium, potassium and chlo- ride occurred from 6:00 A.M. to 12:00 midnight, the minimum excretion from 12 midnight to 6:00 A.M.He concluded that the diurnal variation of water and mineral excretion is related to sleep rather than to changes in physical activity.Simpson (5) was unable to affect the cycle by means of dehydration, fasting, changes in posture or short periods of sleep during the day.Norn (6) re- ported a reversal of the cycle with respect to time in a night watchman who obtained his normal com- plement of sleep, during the day.Brod (7) showed that normal subjects have depressed en- dogenous "creatinine" clearances at night associ- ated with diminished urine flow.It has been adequately demonstrated that ...