Reactome knowledgebase of human biological pathways and processes

作者：Lisa R. Matthews, Gopal Gopinath, Marc E. Gillespie, Michael A. Caudy, David Croft, Bernard de Bono, Phani V Garapati, Jill Hemish, Henning Hermjakob, Bijay Jassal, Alexander A Kanapin, Suzanna Lewis, Sandeep Mahajan, Bruce May, E Schmidt, Imre Västrik, Guanming Wu, Ewan Birney, Lincoln Stein, Peter D’Eustachio · 发表于：Nucleic Acids Research · 年份：2008 · DOI：10.1093/nar/gkn863 · 被引用次数：890 · 研究领域：Bioinformatics and Genomic Networks、Microbial Metabolic Engineering and Bioproduction、Biomedical Text Mining and Ontologies

Reactome (http://www.reactome.org) is an expert-authored, peer-reviewed knowledgebase of human reactions and pathways that functions as a data mining resource and electronic textbook. Its current release includes 2975 human proteins, 2907 reactions and 4455 literature citations. A new entity-level pathway viewer and improved search and data mining tools facilitate searching and visualizing pathway data and the analysis of user-supplied high-throughput data sets. Reactome has increased its utility to the model organism communities with improved orthology prediction methods allowing pathway inference for 22 species and through collaborations to create manually curated Reactome pathway datasets for species including Arabidopsis, Oryza sativa (rice), Drosophila and Gallus gallus (chicken). Reactome's data content and software can all be freely used and redistributed under open source terms.