E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

作者：Joseph R. Nevins · 发表于：Science · 年份：1992 · DOI：10.1126/science.1411535 · 被引用次数：1537 · 研究领域：Cancer-related Molecular Pathways、Virus-based gene therapy research、Neuroblastoma Research and Treatments

The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common mechanism of action for the oncoproteins encoded by the DNA tumor viruses.