Control of Experimental Autoimmune Encephalomyelitis by T Cells Responding to Activated T Cells

作者：Ansgar Wilhelm Lohse, Felix Mor, Nathan Karin, Irun R. Cohen · 发表于：Science · 年份：1989 · DOI：10.1126/science.2471264 · 被引用次数：194 · 研究领域：T-cell and B-cell Immunology、vaccines and immunoinformatics approaches、Artificial Immune Systems Applications

T cell vaccination against experimental autoimmune disease is herein shown to be mediated in part by anti-ergotypic T cells, T cells that recognize and respond to the state of activation of other T cells. The anti-ergotypic response thus combines with the previously shown anti-idiotypic T cell response to regulate autoimmunity.