Gonadotropin Secretion from a Bronchogenic Carcinoma

作者：Charles Faiman, John A. Colwell, Robert J. Ryan, Jerome M. Hershman, Thomas W. Shields · 发表于：New England Journal of Medicine · 年份：1967 · DOI：10.1056/nejm196712282772604 · 被引用次数：105 · 研究领域：TGF-β signaling in diseases、Hypertrophic osteoarthropathy and related conditions、Skin and Cellular Biology Research

THE recent finding of elevated levels of gonadotropins in tumor tissue and urine by bioassay in 4 cases of bronchogenic carcinoma strongly suggests the production of gonadotropins by these neoplasms.1 We have obtained proof of secretion of gonadotropin by a primary pulmonary neoplasm with the demonstration of an arteriovenous gradient of a serum gonadotropin concentration across the tumor bed by the use of a sensitive and specific radioimmunoassay technic for follicle-stimulating hormone (FSH). Luteinizing hormone (LH) concentrations were also determined by a radioimmunoassay technic. These findings are reported below.MethodsTissue ExtractsFresh tissue was obtained at operation and at . . .