Elevation of erythropoietin levels in association with Wilms' tumor.

作者：William G. Thurman, Harry Grabstald, PHILIP H. LIEBERMAN · 发表于：PubMed · 年份：1966 · 被引用次数：25 · 研究领域：Electrolyte and hormonal disorders、Childhood Cancer Survivors' Quality of Life、Potassium and Related Disorders

THE OCCURRENCE of polycythemia in association with various diseases has been frequently recorded. Renal malignancies, uterine myomata, hemangioblastomas and hepatic cell carcinomas have been the malignant tumors most frequently involved.1-4Recent reports have also established the occurrence of polycythemia in association with undifferentiated carcinoma of the lung.5Hematologic remission subsequent to treatment with surgery, radiotherapy, or chemotherapy has been documented in some of these cases. This report presents observations of what we believe to be the first patient with Wilms' tumor to be associated with polycythemia. Plasma from this patient had an increased level of erythropoietin; metastatic nodules in the lung were homogenized and separated, and the supernatant fluid had erythropoietin activity. Methods of Investigation Presurgical and postsurgical erythropoietin levels were determined by bioassay in starved rats. Female Sprague-Dawley rats weighing approximately 200 gm each were starved for 96 hours. Thirty and 54 hours after starvation was instituted,