Linkage of a Cardiac Arrhythmia, the Long QT Syndrome, and the Harvey ras -1 Gene

作者：Mark E. Keating, Donald L. Atkinson, Christine Dunn, Katherine W. Timothy, G. Michael Vincent, Mark Leppert · 发表于：Science · 年份：1991 · DOI：10.1126/science.1673802 · 被引用次数：524 · 研究领域：Cardiac electrophysiology and arrhythmias、Ion channel regulation and function、Receptor Mechanisms and Signaling

Genetic factors contribute to heart disease. In this study, linkage analyses have been performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at theta = 0, which confirms the genetic basis of this trait and localizes this gene to the short arm of chromosome 11. As no recombination was observed between LQT and H-ras-1, and there is a physiological rationale for its involvement in this disease, ras becomes a candidate for the disease locus.