The Obesity Epidemic: Pathophysiology and Consequences of Obesity

作者：F. Xavier Pi‐Sunyer · 发表于：Obesity Research · 年份：2002 · DOI：10.1038/oby.2002.202 · 被引用次数：861 · 研究领域：Obesity, Physical Activity, Diet、Nutritional Studies and Diet、Diabetes, Cardiovascular Risks, and Lipoproteins

Obesity has reached epidemic proportions in the United States: more than 20% of adults are clinically obese as defined by a body mass index of 30 kg/m(2) or higher, and an additional 30% are overweight. Environmental, behavioral, and genetic factors have been shown to contribute to the development of obesity. Elevated body mass index, particularly caused by abdominal or upper-body obesity, has been associated with a number of diseases and metabolic abnormalities, many of which have high morbidity and mortality. These include hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, coronary heart disease, gallbladder disease, and certain malignancies. This underscores the importance of identifying people at risk for obesity and its related disease states.