THE DETECTION AND ESTIMATION OF GLUCOSE IN URINE

作者：Stanley R. Benedict · 发表于：JAMA · 年份：1911 · DOI：10.1001/jama.1911.04260100019005 · 被引用次数：125 · 研究领域：Metabolism and Genetic Disorders、Renal function and acid-base balance、Diet, Metabolism, and Disease

USE many , .'.""I'c'y possessed by glucose, in com mon with 'bie so] r' 1' su.»iU's' "'' rcadilv taking up oxygen in alka- of deti V""1' 's alinosi universally employed as n meansThe I *1*8 tllÍS Sl'lls,:'0''e in urine. ,.(ii!i| glucose n,"le,."i,,¡tae]^however, is not the active l >i c\i ,mí?l 8u"stance in alkaline solution, it having been 11 aubst sbovvii' that the reducing action is due to "".-"' i l i ' oi ?formed from the action of alkali on the 18 Hot st°n U r'''ü reducing substance thus formed to exhüYt -f iinxnv<] strong alkali, and unless permitted )K,s,.(|j" l,s reducing action ai once, is rapidly decom- lf Bodiu ''onipminds which have no reducing power, Of ,||(, ' ,",' °''.potassium hydroxid be present'.Solutions reducing I earDonates, on the other hand, form the than tl ,if" ance 'mm glucose a little more slowly tive acti ''^''''ovids, and have little, if any, deslnio- fojjjj.on °n the reducing substance after it has been that th! a '"nsil|"ration of these facts it may be inferred '"">'.onJ1' 6861106 ' •' ' ' ""' BtronS !l,ki,,i '" ^'bung's fluid I"IVv(' t of +v(t''''"'" circumstances, interfere with the "' sU"nr i°r instance, contains compounds by Jlaél !l 0l ' -K w'li<'1' is probably creatinin.as pointed out tioa0f ean), which seriously interfere with the detec- liiin\ ¿' "coseby Folding's solution.Thus, although I'Vli- ' ""' •solu,' wi" ,l''1"1'' 0.001 per cent, of glucose in ')(i l'l'esei f 10' 11' "' .' lMS' a buiulred times this amount must reagen1 ' ' im".'...