Structure and Function in the Nucleus

作者：Angus I. Lamond, William C. Earnshaw · 发表于：Science · 年份：1998 · DOI：10.1126/science.280.5363.547 · 被引用次数：932 · 研究领域：Nuclear Structure and Function、RNA Research and Splicing、Neurogenetic and Muscular Disorders Research

Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.