τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ

作者：Hirotaka Yoshida, Yasuo Ihara · 发表于：Journal of Neurochemistry · 年份：1993 · DOI：10.1111/j.1471-4159.1993.tb03642.x · 被引用次数：232 · 研究领域：Cancer-related gene regulation、Wnt/β-catenin signaling in development and cancer、RNA modifications and cancer

tau in paired helical filaments (PHF-tau) and fetal tau share several phosphorylated epitopes, as revealed by several phosphorylation-dependent PHF monoclonals. We have asked whether there is any difference between the two molecules in tubulin assembly-promoting activity and found that PHF-tau is almost assembly incompetent, whereas fetal tau is low in this activity but still assembly competent. This indicates that despite substantial similarities in immunoreactivities, PHF-tau and fetal tau are quite distinct from each other in function.