PHOTODYNAMIC TREATMENT OF THE DERMATOPHYTE TRICHOPHYTON RUBRUM AND ITS MICROCONIDIA WITH PORPHYRIN PHOTOSENSITIZERS

作者：Threes G. M. Smijs, Richard N. S. van der Haas, Johan Lugtenburg, Yan Liu, Rob L. P. de Jong, Hans J. Schuitmaker · 发表于：Photochemistry and Photobiology · 年份：2004 · DOI：10.1562/2004-04-22-ra-146 · 被引用次数：81 · 研究领域：Photodynamic Therapy Research Studies、Nail Diseases and Treatments、Antifungal resistance and susceptibility

The application of photosensitizers for the treatment of fungal infections is a new and promising development within the field of photodynamic treatment (PDT). Dermatophytes, fungi that can cause infections of the skin, hair and nails, are able to feed on keratin. Superficial mycoses are probably the most prevalent of infectious diseases in all parts of the world. One of the most important restrictions of the current therapeutic options is the return of the infection and the duration of the treatment. This is especially true in the case of infections of the nail (tinea unguium) caused by Trichophyton rubrum, an anthropophilic dermatophyte with a worldwide distribution. Recently, we demonstrated that 5,10,15-tris(4-methylpyridinium)-20-phenyl-[21H,23H]-porphine trichloride (Sylsens B) and deuteroporphyrin monomethylester were excellent photosensitizers toward T. rubrum when using broadband white light. This study demonstrates the photodynamic activity of these photosensitizers with red light toward both a suspension culture of T. rubrum and its isolated microconidia. The higher penetration depth of red light is important for the PDT of nail infections. In addition, we tested the photodynamic activity of a newly synthesized porphyrin, quinolino-[4,5,6,7-efg]-7-demethyl-8-deethylmesoporphyrin dimethylester, displaying a distinct peak in the red part of the spectrum. However, its photodynamic activity with red light toward a suspension culture of T. rubrum appeared to be only fun...