Mesenchyme-Dependent Morphogenesis and Epithelium-Specific Cytodifferentiation in Mouse Mammary Gland

作者：Teruyo Sakakura, Yasuaki Nishizuka, Clyde J. Dawe · 发表于：Science · 年份：1976 · DOI：10.1126/science.827022 · 被引用次数：358 · 研究领域：Infant Nutrition and Health

Isografts of heterotypic recombinants of embryonic mammary epithelium with salivary mesenchyme undergo development morphogenetically resembling that of salivary gland. However, cytodifferentiation of the epithelium is like that of mammary gland. In lactating hosts these isografts respond to endogenous hormonal stimulation and synthesize a milk protein, alpha-lactalbumin.