Macrophage Inflammatory Protein-1: a Prostaglandin-Independent Endogenous Pyrogen

作者：George Davatelis, Stephen D. Wolpe, Barbara A. Sherry, Jean‐Michel Dayer, Rachel Chicheportiche, Anthony Cerami · 发表于：Science · 年份：1989 · DOI：10.1126/science.2646711 · 被引用次数：217 · 研究领域：Immune Response and Inflammation、Inflammasome and immune disorders、interferon and immune responses

Macrophage inflammatory protein-1 (MIP-1) produced a monophasic fever of rapid onset whose magnitude was equal to or greater than that of fevers produced with either recombinant human cachectin (or tumor necrosis factor) or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 was not inhibited by the cyclooxygenase inhibitor ibuprofen. Thus, MIP-1 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase inhibitors.