NOR-EPINEPHRINE-LIKE AND EPINEPHRINE-LIKE SUBSTANCES IN PSYCHOTIC AND PSYCHONEUROTIC PATIENTS

作者：Daniel H. Funkenstein, Milton Greenblatt, Harry C. Solomon · 发表于：American Journal of Psychiatry · 年份：1952 · DOI：10.1176/ajp.108.9.652 · 被引用次数：62 · 研究领域：Nicotinic Acetylcholine Receptors Study、Heart Rate Variability and Autonomic Control、Cardiac electrophysiology and arrhythmias

1. Sixty-three patients with elevated blood pressures who were routine admissions to the Boston Psychopathic Hospital were given a standardized dose of mecholyl intramuscularly. On the basis of their blood pressure reactions to the drug during a stated observation period, the patients could be divided into 2 groups: (1) Type A were those in which following the injection of the mecholyl the blood pressure remained below the preinjection level throughout the observation period. (On the basis of previous experimentation (10, 12) this was interpreted as indicating excessive secretion of an epinephrine-like substance.) (2) Group B were those in which following the injection of mecholyl the blood pressure returned to the preinjection level within the observation period. (On the basis of previous experimentation (10, 12) this was interpreted as indicating excessive secretion of a nor-epinephrine-like substance.) When these 2 groups were compared in regard to 2 other variables, the maximum fall in blood pressure after mecholyl, and the area between the mecholyl reaction and the basal blood pressure, the difference between the types was found to be significant at better than the .01 level. 2. Thirty-nine of 42 cases showing evidence interpreted as indicating excessive secretion of an epinephrine-like substance improved with electric shock therapy. In contrast to this, only 3 of 21 cases showing evidence interpreted as indicating excessive secretion of a nor-epinephrine-like substance ...