Stage 4 Sleep in Schizophrenia

作者：Irwin Feinberg · 发表于：Archives of General Psychiatry · 年份：1969 · DOI：10.1001/archpsyc.1969.01740210006002 · 被引用次数：112 · 研究领域：Sleep and Wakefulness Research、Sleep and related disorders、Circadian rhythm and melatonin

THE stage 4 EEG (employing the Dement and Kleitman1nomenclature) of sleep, as measured in our laboratory, consists of high-voltage (over 50V) slow (under 4 cycles per second) activity occurring with a stipulated density (over 16 waves per 20second epoch, or over 50% of the epoch occupied by such slow waves). Stage 3 EEG represents a lesser density (10 to 16 waves per 20-second epoch) of this slow-wave activity. Stage 3 and 4 EEG constitute, along with spindles and K-complexes, the distinguishing features of nonrapid eye-movement (NREM) or slow-wave sleep. Both stage 3 and 4 EEG are maximal during the first few hours of sleep1and their distributions across the night may usefully be described as a function of the successive sleep cycles.2 Stage 4 EEG reaches its highest level in early childhood3and then shows a hyper