Alzheimer's Disease, Trisomy 21, and Myeloproliferative Disorders: Associations Suggesting a Genetic Diathesis

作者：Leonard L. Heston · 发表于：Science · 年份：1977 · DOI：10.1126/science.196.4287.322 · 被引用次数：110 · 研究领域：Microtubule and mitosis dynamics、Amyloidosis: Diagnosis, Treatment, Outcomes

Relatives of probands with Alzheimer's disease had excessive incidences of trisomy 21 and myeloproliferative disorders. Microtubules are structures that are likely to be affected by a genetic defect causing a predisposition to Alzheimer's disease, trisomy 21 and, possibly, to myeloproliferative disorders.