Post-translational Regulation of Runx2 in Bone and Cartilage

作者：Jennifer H. Jonason, Guozhi Xiao, M. Zhang, Lianping Xing, D. Chen · 发表于：Journal of Dental Research · 年份：2009 · DOI：10.1177/0022034509341629 · 被引用次数：160 · 研究领域：Bone Metabolism and Diseases、Bone health and treatments、NF-κB Signaling Pathways

The Runx2 gene product is essential for mammalian bone development. In humans, Runx2 haploinsufficiency results in cleidocranial dysplasia, a skeletal disorder characterized by bone and dental abnormalities. At the molecular level, Runx2 acts as a transcription factor for genes expressed in hypertrophic chondrocytes and osteoblasts. Runx2 gene expression and protein function are regulated on multiple levels, including transcription, translation, and post-translational modification. Furthermore, Runx2 is involved in numerous protein-protein interactions, most of which either activate or repress transcription of target genes. In this review, we discuss expression of Runx2 during development as well as the post-translational regulation of Runx2 through modification by phosphorylation, ubiquitination, and acetylation.