Altering the course of cataracts in diabetic rats.

作者：Suguru Fukushi, LORENZO O. MEROLA, J. H. Kinoshita · 发表于：PubMed · 年份：1980 · 被引用次数：107 · 研究领域：Aldose Reductase and Taurine、Connexins and lens biology、Biochemical effects in animals

A potent new aldose reductase (AR) inhibitor was effective in preventing cataractous changes in diabetic rats. Untreated diabetic rats developed early lens changes by 3 weeks and dense nuclear opacities by 6 to 9 weeks. In contrast, diabetic rats treated with the AR inhibitor showed no lens changes during the 5-month period of the experiment.