Prolactin Receptors in Rat Liver: Possible Induction by Prolactin

作者：Barry I. Posner, Paul A. Kelly, Henry G. Friesen · 发表于：Science · 年份：1975 · DOI：10.1126/science.163493 · 被引用次数：257 · 研究领域：Growth Hormone and Insulin-like Growth Factors、Hormonal Regulation and Hypertension

A prolactin receptor, present in adult female rat liver, can be induced in males by estrogen. Hypophysectomy diminished receptor levels in the female and rendered males unresponsive to estrogen. A renal pituitary implant blunted the decrease in hypophysectomized females and induced the receptor in hyophysectomized males. The increased receptor level in hypophysectomized males with a renal pituitary implant was preceded by a sustained elevation of circulating prolactin. Our observations suggest that prolactin induces its own receptor.