Overexpression of Wnt-2 in colorectal cancers

作者：Joo Hun Park, Jiaxi Song, Taiping He, Sang‐Jip Nam, Jae‐Seong Lee, Won Park · 发表于：Neoplasma · 年份：2009 · DOI：10.4149/neo_2009_02_119 · 被引用次数：36 · 研究领域：Wnt/β-catenin signaling in development and cancer、Cancer Cells and Metastasis、Neuropeptides and Animal Physiology

UNLABELLED: The binding of the Wnt ligand to its receptor Frizzled, activates the Wnt canonical signaling pathway in carcinogenesis as well as many cellular processes, including cellular proliferation and differentiation. Wnt-2, one of 19 members of the Wnt gene family, is frequently overexpressed in malignant tissues. Here, in order to investigate the role of Wnt-2 in colorectal carcinogenesis, we examined the expression of the Wnt-2 protein in 120 colorectal cancers by immunohistochemistry. Wnt-2 protein was expressed in the cell membrane and cytoplasm and up-regulated in 74 (61.7%) of 120 colorectal cancers. Statistically, overexpression of Wnt-2 protein was not associated with the clinical and pathological parameters studied, including tumor location, tumor size, clinical stage, lymph node metastasis, and 5-year survival (P > 0.05). These results indicate that up-regulation of the Wnt-2 protein might play a role in the development of colorectal cancers, as an early event of carcinogenesis. KEYWORDS: Wnt-2 protein, expression, immunohistochemistry, tissue microarray, colon cancer.