The history of clozapine and its emergence in the US market

作者：John Crilly · 发表于：History of Psychiatry · 年份：2007 · DOI：10.1177/0957154x07070335 · 被引用次数：275 · 研究领域：Schizophrenia research and treatment、Mental Health and Psychiatry、Neurology and Historical Studies

Clozapine is known as the first 'atypical' medication and is effective in people who have treatment-resistant schizophrenia. Its 1990 emergence in the USA was marked by considerable controversy over its high cost, due in large part to having been both the first new antipsychotic medication to come to market in over a decade and the need for comprehensive safety monitoring within a decentralized health system. This paper traces the history of clozapine's discovery and development in Europe, its part in the 1975 Finnish agranulocytosis scare, and its subsequent volatile emergence in the USA. Analyses examine peripheral forces at the time, particularly the influence of political, corporate, medical and societal forces which shaped its market course.