Linking Data From the Multiethnic Cohort Study to Medicare Data: Linkage Results and Application to Chronic Disease Research

作者：Veronica Wendy Setiawan, Beth A Virnig, Jacqueline Porcel, Brian E. Henderson, Loı̈c Le Marchand, Lynne Ross Wilkens, Kristine R. Monroe · 发表于：American Journal of Epidemiology · 年份：2015 · DOI：10.1093/aje/kwv055 · 被引用次数：56 · 研究领域：Nutritional Studies and Diet、Nutrition and Health in Aging、Cardiovascular Health and Risk Factors

The Multiethnic Cohort Study of Diet and Cancer (MEC), a prospective study, was established between 1993 and 1996 to study risk factors for cancer by taking advantage of the ethnic and cultural diversity of Hawaii and California (1). The cohort included more than 215,000 men and women and was comprised of 5 racial/ethnic populations. At recruitment, the participants were aged 45–75 years. By 2013, more than 90% of surviving participants had become eligible for Medicare (aged ≥65 years). Given its ethnic diversity, the value of MEC for etiological research on cancer is widely recognized (2). To expand and identify health outcomes, we recently completed a study of linkage of MEC data to Centers for Medicare & Medicaid Services claim data. Medicare claims have been widely used as a population-based source of data for research (3–6). Here, we describe the success of linking MEC with Medicare data and use congestive heart failure (CHF) to illustrate its value for etiological research. The characteristics of MEC have been described previously (1). The baseline questionnaire and 4 follow-up questionnaires assessed diet, lifestyle, anthropometric factors, and familial and personal medical history. Between 1995 and 2006, blood and urine specimens were collected from approximately 70,000 participants for genetic and biomarker studies. The participants who reached age 65 years, including those who were deceased, were linked to Medicare records using Social Security number, sex, and birt...