RIGIN, ANOTHER PHAGOCYTOSIS‐STIMULATING TETRAPEPTIDE ISOLATED FROM HUMAN IgG: Confirmations of a Hypothesis

作者：N. Veretennikova, G. I. Chipens, Gregory V. Nikiforovich, YA. R. BETINSH · 发表于：International journal of peptide & protein research · 年份：1981 · DOI：10.1111/j.1399-3011.1981.tb02011.x · 被引用次数：33 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Transgenic Plants and Applications、Influenza Virus Research Studies

Structure-function and conformational studies of the molecule of phagocytosis-stimulating tetrapeptide tuftsin permitted the conclusion that among products resulting from splitting of H-chain of IgG Human EU by trypsin, besides tuftsin (sequence 289-292), tuftsin-like tetrapeptide Gly-Gln-Pro-Arg may be also present; theoretical conformational analysis shows a considerable similarity of spatial arrangement of this tetrapeptide and tuftsin which testifies in favour of potential tuftsin-like activity of the tetrapeptide. Gly-Gln-Pro-Arg was synthesized and its phagocytosis stimulating activity was found equal to that of tuftsin.