Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation

作者：Laurence A. Lasky · 发表于：Science · 年份：1992 · 被引用次数：1248 · 研究领域：Cell Adhesion Molecules Research、Glycosylation and Glycoproteins Research、Monoclonal and Polyclonal Antibodies Research

Although a bewildering array of cell surface carbohydrate structures have been described, the physiological relevance of any of these complex molecules has often eluded biologists. A family of cell surface glycoproteins, the "selectins," has a characteristic ability to use some of these carbohydrate structures in adhesive mechanisms that help localize leukocytes to regions of inflammation. This article will review the biology of these carbohydrate-binding adhesive proteins and discuss the potential for developing anti-inflammatory antagonists that could inhibit binding events that are selectin-mediated.