Origin and Biologic Individuality of the Genetic Dictionary

作者：Dario Giacomoni, Sol Spiegelman · 发表于：Science · 年份：1962 · DOI：10.1126/science.138.3547.1328 · 被引用次数：140 · 研究领域：RNA and protein synthesis mechanisms、DNA and Nucleic Acid Chemistry、Genomics and Chromatin Dynamics

Deoxyribonucleic acid contains sequences complementary to homologous amino-acid transfer ribonucleic acid molecules which serve as the translating device between polyribonucleotides and proteins. This implies that the RNA molecules have their primary origin in DNA. From the amount of DNA participating, one would infer that more than 20 complementary sequences exist per genome, a conclusion consistent with a degenerate code. The fact that complex formation occurs most readily with homologous RNA suggests that, while the language remains universal, each dictionary is uniquely identifiable with its own genome.