Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey

作者：Thomas J. Brozoski, Roger M. Brown, H. Enger Rosvold, Patricia S. Goldman · 发表于：Science · 年份：1979 · DOI：10.1126/science.112679 · 被引用次数：1522 · 研究领域：Functional Brain Connectivity Studies、Neurotransmitter Receptor Influence on Behavior、Neural dynamics and brain function

Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function.