Phosphorylated Proteins as Physiological Effectors

作者：Paul Greengard · 发表于：Science · 年份：1978 · DOI：10.1126/science.22932 · 被引用次数：972 · 研究领域：Mitochondrial Function and Pathology、Cancer, Hypoxia, and Metabolism、Muscle metabolism and nutrition

A variety of neurotransmitters, hormones, and other regulatory agents affect the phosphorylation of specific proteins in their target tissues. The types of stimuli that share this common effect on protein phosphorylation include numerous substances that do not act through cyclic AMP. These and other observations suggest that many different classes of regulatory substances achieve certain of their biological effects by altering the phosphorylation of specific proteins.