Coordinated Polar Localization of Auxin Efflux Carrier PIN1 by GNOM ARF GEF

作者：Thomas Steinmann, Niko Geldner, Markus Grebe, Stefan Mangold, Catherine L. Jackson, Sonia Paris, Leo Gälweiler, Klaus J. Palme, Gerd Jürgens · 发表于：Science · 年份：1999 · DOI：10.1126/science.286.5438.316 · 被引用次数：771 · 研究领域：Plant Molecular Biology Research、Plant nutrient uptake and metabolism、Plant Reproductive Biology

The plant hormone auxin is transported in a polar manner along the shoot-root axis, which requires efflux carriers such as PIN1. Asymmetric localization of PIN1 develops from a random distribution in Arabidopsis early embryogenesis. Coordinated polar localization of PIN1 is defective in gnom embryos. GNOM is a membrane-associated guanine-nucleotide exchange factor on ADP-ribosylation factor G protein (ARF GEF). Thus, GNOM-dependent vesicle trafficking may establish cell polarity, resulting in polar auxin transport.