GENETIC ANALYSIS OF SUSCEPTIBILITY TO EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN GUINEA‐PIGS

作者：Dvora Teitelbaum, Ruth Arnon · 发表于：International Journal of Immunogenetics · 年份：1981 · DOI：10.1111/j.1744-313x.1981.tb00748.x · 被引用次数：14 · 研究领域：Chemical Synthesis and Analysis、Monoclonal and Polyclonal Antibodies Research、RNA and protein synthesis mechanisms

Genetic analysis of susceptibility to experimental allergic encephalomyelitis (EAE) was performed in guinea-pigs. The results indicate the existence of two Ir genes to EAE in susceptible strain 13 guinea-pigs. One gene is linked to the major histocompatibility complex (MHC) of this species, while the other one is located outside the MHC. The two genes segregate independently and both of them must be expressed to render the animal susceptible to EAE.