A New Separation Concept Based on a Coupling of Concentration and Flow Nonuniformities

作者：J. Calvin Giddings · 发表于：Separation Science · 年份：1966 · DOI：10.1080/01496396608049439 · 被引用次数：414 · 研究领域：Microfluidic and Capillary Electrophoresis Applications、Microfluidic and Bio-sensing Technologies、Analytical Chemistry and Chromatography

Described here is a new separation concept which theory shows to have considerable potential for analytical-scale work. Like chromatography, separation is achieved by differential migration in a narrow tube through which fluid is flowing unidirectionally. Unlike chromatography, separation is brought about in a one phase (or at least a continuous phase) system. It should not only be applicable to chromatography-type separations, but, more important, it should exhibit a distinct advantage in separating macromolecules and colloids, because of its essentially one-phase nature.