Aspects of the Rationale for the Women's Health Trial

作者：Ross L. Prentice, Faizullah Kakar, Stephen D. Hursting, Lianne Sheppard, Robert Klein, Lawrence H. Kushi · 发表于：JNCI Journal of the National Cancer Institute · 年份：1988 · DOI：10.1093/jnci/80.11.802 · 被引用次数：206 · 研究领域：Cancer, Lipids, and Metabolism、Cancer Risks and Factors、Genetic factors in colorectal cancer

A 5.5-fold range in breast cancer incidence rates in 21 countries shows strong correlation with national estimates of per capita intake of dietary fat, but not with other caloric sources (proteins and carbohydrates). It is argued that certain breast cancer and hormone factors may contribute little to the explanation of such international variations in incidence of this neoplasm. It is further argued that experimental studies in animals support a specific role for dietary fat in the promotion of mammary tumors, but the effects of calories alone seem to be largely restricted to tumor initiation. Finally, data from international, migrant-population, and analytic epidemiologic investigations are used to motivate the basic relative risk assumption of study designs thus far proposed for the Women's Health Trial, and some continuing motivations for a dietary intervention (low-fat diet) trial are discussed.