A new method to test genetic models in HLA associated diseases: the MASC method

作者：Françoise Clerget‐Darpoux, Marie‐Claude Babron, Bernard Prum, G.M. Lathrop, Ingeborg Deschamps, JACQUES HORS · 发表于：Annals of Human Genetics · 年份：1988 · DOI：10.1111/j.1469-1809.1988.tb01102.x · 被引用次数：83 · 研究领域：Diabetes and associated disorders、T-cell and B-cell Immunology、Genomic variations and chromosomal abnormalities

We propose a new method to analyse data on HLA associated diseases. The method uses the simultaneous information on the marker associations and segregation with the disease. It may also take into account the differential risk of being affected for specific relatives of a patient as well as the differential HLA haplotype sharing according to the marker genotype of the patient. It is based on the principle of minimization of a sum of independent chi-squares. It allows us to test the goodness-of-fit of various models in an easy and economical way. The method is applied to a sample of 269 French IDDM patients and their relatives leading to the rejection of models with one locus closely linked to HLA with two and three alleles.