Effects of Long-Term Administration of Estrogens on Serum Lipids of Postmenopausal Women

作者：Roger W. Robinson, Norio Higano, William Cohen · 发表于：New England Journal of Medicine · 年份：1960 · DOI：10.1056/nejm196010272631703 · 被引用次数：41 · 研究领域：Estrogen and related hormone effects、Menopause: Health Impacts and Treatments

IT is now well recognized that the incidence of coronary-artery disease is increased in the post-menopausal state.1 , 2 A possible explanation for this association is the presence of abnormal serum lipid levels, not only in postmenopausal3 and prematurely castrated women4 but also in those with Coronary Artery disease.3 , 5 Thus, decreased ovarian function has been suggested as one of several possible etiologic factors in atherosclerosis. Since this appears to be a rational basis for estrogen replacement therapy in the postmenopausal state, the purpose of the present study was to determine the daily dosage of estrogen required to attain optimal lipid changes with . . .