Alcohol, Other Drugs, and the Liver

作者：Emanuel Rubin, Charles S. Lieber · 发表于：Annals of Internal Medicine · 年份：1968 · DOI：10.7326/0003-4819-69-5-1063 · 被引用次数：16 · 研究领域：Pharmacogenetics and Drug Metabolism、Drug-Induced Hepatotoxicity and Protection、Metabolism and Genetic Disorders

Editorials1 November 1968Alcohol, Other Drugs, and the LiverEMANUEL RUBIN, M.D., CHARLES S. LIEBER, M.D.EMANUEL RUBIN, M.D., CHARLES S. LIEBER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-5-1063 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last decade numerous biochemical and ultrastructural studies have greatly expanded our understanding of the mechanisms involved in drug metabolism. Comprehensive recent reviews of this subject include those of Conney (1), Remmer (2), and Gillette (3). Most exogenous substances—such as pharmacologic agents, carcinogens, and insecticides—are detoxified by enzyme systems located in the microsomal fraction of the liver cell, which corresponds to the membranes of the endoplasmic reticulum seen with the electron microscope. Detoxification generally involves conversion of the molecule to a more polar form, thus rendering lipid soluble materials more water soluble for urinary excretion. This is usually accomplished...References1. CONNEY AH: Pharmacological implications of microsomal enzyme induction. Pharmacol. Rev. 19: 317, 1967. MedlineGoogle Scholar2. REMMER H: Induction of drug metabolizing enzymes in the endoplasmic reticulum of the liver by treatment with drugs. German Med. Monthly 13: 53, 1968. MedlineGoogle Scholar3. GILLETTE JR: Biochemistry of drug oxidation and reduction by enzymes in hepatic endoplasmic...