Pd(II)-Catalyzed Cross-Coupling of sp3 C−H Bonds with sp2 and sp3 Boronic Acids Using Air as the Oxidant

作者：Dong‐Hui Wang, Masayuki Wasa, Ramesh Giri, Jin‐Quan Yu · 发表于：Journal of the American Chemical Society · 年份：2008 · DOI：10.1021/ja801355s · 被引用次数：501 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Oxidative Organic Chemistry Reactions

O-Methyl hydroxamic acids, readily available from carboxylic acids, are found to be extremely reactive for beta-C-H activation by Pd(OAc)2. This reactivity is exploited to develop the first example of cross-coupling sp3 C-H bonds with sp3 boronic acids. Air was shown to be a suitable stoichiometric oxidant for the catalytic oxidative coupling reaction. A biologically active natural product is readily converted to its novel analogues through this coupling reaction.