Metabolites of the higher fungi. Part 26. Cubensic acid, 3,7,11,15-tetra hydroxy-18-(hydroxymethyl)-2,4,6,10,14,16,20-heptamethyldocosa-4E,8E,12E,16E-tetraenoic acid, a novel polysubstituted C22 fatty acid from the fungus Xylaria cubensis(Mont.) Fr. with substituents and substitution pattern similar to the macrolide antibiotics

作者：Raymond L. Edwards, Derek J. Maitland, Anthony J. S. Whalley · 发表于：Journal of the Chemical Society Perkin Transactions 1 · 年份：1991 · DOI：10.1039/p19910001411 · 被引用次数：28 · 研究领域：Microbial Natural Products and Biosynthesis、Fungal Biology and Applications、Plant Pathogens and Fungal Diseases

Cubensic acid, 3,7,11,15-tetrahydroxy-18-(hydroxymethyl)-2,4,6,10,14,16,20-heptamethyldocosa-4E,8E,12E,16E-tetraenoic acid, has been isolated from the mycelium and culture medium of Xylaria cubensis. Cytochalasin D is an additional metabolite isolated from the culture medium. The structure of cubensic acid has been determined by a combination of spectroscopic and chemical methods. A possible biosynthetic link between cubensic acid and certain macrolide antibiotics is suggested.