Coumarins from Campylotropis hirtella (FRANCH.) SCHINDL. and Their Inhibitory Activity on Prostate Specific Antigen Secreted from LNCaP Cells

作者：Huiying Han, Ping Wen, Hongwei Liu, Naili Wang, Xin‐Sheng Yao · 发表于：Chemical and Pharmaceutical Bulletin · 年份：2008 · DOI：10.1248/cpb.56.1338 · 被引用次数：21 · 研究领域：Plant chemical constituents analysis、Phytochemistry and Biological Activities、Sesquiterpenes and Asteraceae Studies

Campylotropis hirtella (FRANCH.) SCHINDL. was used as a folk medicine for the treatment of benign prostate hyperplasia (BPH) in China. In this study, two new coumarins, 7,2',4'-trihydroxy-5-methoxy-3-arylcoumarin (1), 6-[(1S,2S)-2-angeloyloxy-1,3-dihydroxy-3-methylbutyl]-7-methoxycoumarin, named angelol M (2), together with eleven known related compounds (3-13) were isolated from this plant under the bioassay guided fractionation. All the compounds showed activity with different levels in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells, using ELISA method.