Interaction of α‐synuclein and tau genotypes in Parkinson's disease

作者：Catherine Mamah, Timothy G. Lesnick, Sarah Lincoln, Kari J. Strain, Mariza de Andrade, James H. Bower, J. Eric Ahlskog, Walter A. Rocca, Matthew J. Farrer, Demetrius M. Maraganore · 发表于：Annals of Neurology · 年份：2005 · DOI：10.1002/ana.20387 · 被引用次数：47 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Neurological disorders and treatments、Alzheimer's disease research and treatments

To determine whether the microtubule-associated protein tau (MAPT) and alpha-synuclein (SNCA) genes interact to confer Parkinson's disease (PD) susceptibility, we conducted a study of 557 case-control pairs. There was an increased risk of PD for persons with either SNCA 261/261 or MAPT H1/H1 genotypes as compared with persons with neither (odds ratio, 1.96; 95% confidence interval, 1.34-2.86; p = 0.0003). However, the combined effect of the two genotypes was the same as for either of the genotypes alone (separate and equal). These findings are consistent with in vitro experiments that revealed tau-mediated fibrillization of alpha-synuclein protein at low concentrations (dose threshold effect).